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ENDOTOXIN LIPOPOLYSACCHARIDE FROM ESCHERICHIA-COLI AND ITS EFFECTS ON THE PHAGOCYTIC FUNCTION OF SYSTEMIC AND PULMONARY MACROPHAGES IN TURKEYS
被引：14
|作者：
EMERY, DA
NAGARAJA, KV
SIVANANDAN, V
LEE, BW
ZHANG, CL
NEWMAN, JA
机构：
[1] Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, Paul
关键词：
D O I：
10.2307/1591627
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The effect of Escherichia coli lipopolysaccharide (LPS) on the competence of pulmonary macrophages and phagocytic cells from the systemic circulation of turkeys was examined using luminol-enhanced zymosan-stimulated chemiluminescence. The results showed a rapid and accelerated oxidative burst in both systemic and pulmonary macrophages in LPS-treated turkeys that was significantly greater than in untreated controls. However, this increased oxidative metabolism induced by LPS was not associated with enhanced intracellular bacterial killing by pulmonary macrophages. Turkeys treated with LPS showed a highly significant decrease in pulmonary bactericidal activity against Staphylococcus aureus challenge, indicating a defect in pulmonary macrophage function induced by LPS.
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页码：901 / 909
页数：9
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