ANTIALLERGIC AND ANTIINFLAMMATORY ACTIONS OF 2'-(TETRAZOLE-5-YL)-4-HYDROXY-2-METHYL-2H-1,2-BENZOTHIAZINE-3-CARBOXANILIDE 1,1-DIOXIDE

被引：19
|
作者：
IKEDA, T [1 ]
KAKEGAWA, H [1 ]
MIYATAKA, H [1 ]
MATSUMOTO, H [1 ]
SATOH, T [1 ]
机构：
[1] TOKUSHIMA BUNRI UNIV, FAC PHARMACEUT SCI, YAMASHIRO CHO, TOKUSHIMA 770, JAPAN
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 07期
关键词：
D O I：
10.1016/S0960-894X(00)80397-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
2'-(Tetrazole-5-yl)-4-hydroxy-2-methyl-2H-1, 2-benzothiazine-3-carbox-anilide 1, 1-dioxide which was designed by the structural hybridization of tranilast and piroxicam, markedly exhibited the inhibitory effects on the antigen-induced histamine release from rat PEC, 48 h homologous PCA in rats and the carrageenin-induced paw edema in mice
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收藏
页码：709 / 714
页数：6
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