ABERRANT EXPRESSION OF THE TUMOR SUPPRESSOR GENE P53 IS VERY FREQUENT IN WILMS-TUMORS

被引：36
|
作者：
LEMOINE, NR [1 ]
HUGHES, CM [1 ]
COWELL, JK [1 ]
机构：
[1] INST CHILD HLTH,DEPT HAEMATOL & ONCOL,ICRF ONCOL GRP,LONDON WC1N 1EH,ENGLAND
来源：
JOURNAL OF PATHOLOGY | 1992年 / 168卷 / 02期
关键词：
TUMOR SUPPRESSOR GENE; P53; WILMS TUMOR; IMMUNOHISTOCHEMISTRY;
D O I：
10.1002/path.1711680213
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A series of 34 Wilms' tumours have been analysed for abnormal expression of the tumour suppressor gene p53 using frozen section immunohistochemistry. All tumours showed immunoreactivity with at least one of the specific antibodies used (monoclonal antibody PAb240, polyclonal antibodies CM1 and JG8). Abnormalities of p53 expression are very frequent in this type of childhood tumour.
引用
收藏
页码：237 / 242
页数：6
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