OVARIAN-CYST FORMATION IN 2 PREMENOPAUSAL PATIENTS TREATED WITH TAMOXIFEN FOR BREAST-CANCER

被引：26

作者：

SHULMAN, A ^{[1
]}

COHEN, I ^{[1
]}

ALTARAS, MM ^{[1
]}

MAYMON, R ^{[1
]}

BENNUN, I ^{[1
]}

TEPPER, R ^{[1
]}

BEYTH, Y ^{[1
]}

机构：

[1] TEL AVIV UNIV,ASSAF HAROFE HOSP,SACKLER SCH MED,DEPT OBSTET & GYNAECOL,RAMAT AVIV,ISRAEL

来源：

HUMAN REPRODUCTION | 1994年 / 9卷 / 08期

关键词：

BREAST CANCER; GNRH; ESTROGENS; PRE-MENOPAUSE; TAMOXIFEN;

D O I：

10.1093/oxfordjournals.humrep.a138723

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Pre-menopausal tamoxifen treatment causes hyperoestrogen production and ovarian cyst formation. Two pre-menopausal breast cancer patients who were treated with tamoxifen developed both permanent supraphysiological oestrogen concentration and ovarian cysts. Serum oestrogen decreased to post-menopausal concentrations and ovarian cysts completely resolved during and following simultaneous treatment with tamoxifen and gonadotrophin-releasing hormone agonist (GnRHa). In pre-menopausal breast cancer patients, GnRHa may prevent possible side-effects of tamoxifen, such as ovarian cysts and supraphysiological oestrogen production.

引用

页码：1427 / 1429

页数：3

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