COMPARATIVE EFFECTS OF THE POLYCHLORINATED BIPHENYL MIXTURE, AROCLOR-1242, ON PORPHYRIN AND XENOBIOTIC METABOLISM IN KIDNEY OF JAPANESE-QUAIL AND RAT

被引：10

作者：

MIRANDA, CL ^{[1
]}

HENDERSON, MC ^{[1
]}

WANG, JL ^{[1
]}

NAKAUE, HS ^{[1
]}

BUHLER, DR ^{[1
]}

机构：

[1] OREGON STATE UNIV, DEPT POULTRY SCI, CORVALLIS, OR 97331 USA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 1992年 / 103卷 / 01期

关键词：

D O I：

10.1016/0742-8413(92)90244-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Aroclor 1242 (500 mg/kg, p.o.) produced a marked increase in porphyrin content of quail kidney (1800-fold), and of rat kidney but to a lesser extent (6-fold). 2. Delta-Aminolevulinic acid synthetase activity was increased 12-fold in quail kidney but was unchanged in rat kidney folowing Aroclor 1242 treatment. 3. Uroporphyrinogen decarboxylase activity was significantly inhibited in quail kidney but not in rat kidney. 4. Renal ethoxyresorufin O-deethylase activity was induced in rat and quail whereas renal ethoxycoumarin O-deethylase and glutathione S-transferase activities were induced only in rats by Aroclor 1242.

引用

页码：149 / 152

页数：4

共 17 条

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