SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NOVEL DERIVATIVES 5,7-DIMETHYL-6-PHENYLAZO-3H-THIAZOLO[4,5-B]PYRIDINE-2-ONE

被引：0

作者：

Chaban, Taras ^{[1
]}

Matiychuk, Vasyl ^{[2
]}

Ogurtsov, Volodymyr ^{[1
]}

Chaban, Ihor ^{[3
]}

Harkov, Stefan ^{[4
]}

Nektegaev, Ihor ^{[5
]}

机构：

[1] Danylo Halytsky Lviv Natl Med Univ, Dept Gen Bioinorgan Phys & Colloidal Chem, Pekarska 69, UA-79010 Lvov, Ukraine

[2] Ivan Franko Natl Univ Lviv, Dept Organ Chem, 6 Kyryla & Mcfodia, UA-79005 Lvov, Ukraine

[3] Danylo Halytsky Lviv Natl Med Univ, Dept Pharmaceut Chem, FPGE, Pekarska 69, UA-79010 Lvov, Ukraine

[4] Burgas Univ Prof Dr AsenZlatarov, Med Coll, Dept Pharm, Burgas 8000, Bulgaria

[5] Danylo Halytsky Lviv Natl Mcd Univ, Dept Pharmacol, Pekarska 69, UA-79010 Lvov, Ukraine

来源：

PHARMACIA | 2018年 / 65卷 / 04期

关键词：

synthesis; thiazolo[4,5-b] pyridines; antioxidant activity; anti-inflammatory activity;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Here we describe the synthesis, antioxidant and anti-inflammatory activity of the novel N3 substituted 5,7-dimethyl-6-phenylazo-3H-thiazolo[4,5-b]pyridin-2-ones, who were synthesized in reactions aminomethylation, cyanoethylation, hydrolysis and under the reaction of nucleophilic substitution. The antioxidant activity of the synthesized compounds was evaluated in vitro by the method of scavenging effect on 2,2 diphenyl-1-picrylhydrazyl (DPPH) radicals. The anti-inflammatory action was evaluated in vivo employing the carrageenan-induced rat paw edema method.

引用

页码：51 / 62

页数：12

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