THE EFFECT OF THE ANTIHISTAMINE CIMETIDINE ON ULTRAVIOLET-RADIATION-INDUCED TUMORIGENESIS IN THE HAIRLESS MOUSE

被引：0
|
作者：
MATHESON, MJ [1 ]
REEVE, VE [1 ]
机构：
[1] UNIV SYDNEY, DEPT VET PATHOL, SYDNEY, NSW 2006, AUSTRALIA
来源：
PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1991年 / 53卷 / 05期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This experiment investigated the effect on ultraviolet (UV) radiation-induced tumorigenesis of feeding the histamine type 2 receptor antagonist, cimetidine, to Skh:HR mice. Cimetidine was fed to one group during a 70 day period of chronic UVR (5 days/week for 10 weeks), to a second group from the end of this period to the end of the experiment at 286 days and a third group was fed a control diet only throughout the experiment. Feeding mice cimetidine during the 70 day period of irradiation protected them against the later development of skin tumours.
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页码：639 / 642
页数：4
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