ALCOHOL INDUCTION OF FERRITIN EXPRESSION IN A HUMAN HEPATOBLASTOMA CELL-LINE (HEP-G2)

被引：14
|
作者：
MOIRAND, R [1 ]
LESCOAT, G [1 ]
HUBERT, N [1 ]
DEZIER, JF [1 ]
PASDELOUP, N [1 ]
BRISSOT, P [1 ]
机构：
[1] HOP PONTCHAILLOU, BIOCHIM MED LAB B, F-35011 RENNES, FRANCE
来源：
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1990年 / 14卷 / 06期
关键词：
Alcohol; Ferritin; Human liver cell cultures;
D O I：
10.1111/j.1530-0277.1990.tb01826.x
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Hyperterritinomla, an unclear mechanism, is frequently observed in chronic alcoholics. The aim of this work was to study the effect of alcohol on ferritin expression in a human hepatoblastoma cell line, HepG2. This cell line proved to be sensitive to alcohol, since alcohol increased γ‐GT activity both in cells and media. The most striking result was the increase of ferritin in cells and media by alcohol. Moreover, this effect was specific, since it contrasted with a decrease in total protein synthesis and secretion, a decrease in transferrin excretion and a lack of effect on orosomucoid. In our model, alcohol was able to induce, in a specific manner, ferritin expression. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码：847 / 852
页数：6
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