AN ACID-CLEAVABLE LINKER STABLE AT NEUTRAL PH THAT RELEASES DOXORUBICIN AT LYSOSOMAL PH

被引：2
|
作者：
DUBOWCHIK, GM
PADILLA, LM
FIRESTONE, RA
机构：
[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Wallingford, CT 06492-7660
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 12期
关键词：
D O I：
10.1016/S0960-894X(01)80776-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A Kemp's triacid amide of doxorubicin (DOX), esterified at a second carboxyl, releases DOX at lysosomal pH at a reasonable rate but is extremely stable at neutral pH.
引用
收藏
页码：2843 / 2846
页数：4
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