KERATIN AS A FACTOR IN HISTOPATHOLOGIC DIAGNOSIS

被引:1
|
作者
SHAPIRO, SH
机构
[1] Histotechnology, Queens Hospital Center (Affiliated with Long Island Jewish Medical Center), NY, 11432, 82-68 164th Street, Queens Hospital Center
关键词
ELECTRON MICROSCOPY; EPITHELIAL CELLS; IMMUNOCYTOCHEMISTRY; KERATIN;
D O I
10.1179/his.1991.14.1.51
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Keratin, a fibrous protein in eukaryotic epithelial cells, consists primarily of intermediate filaments, of which at least 19 immunologically distinct proteins have been characterized. The identification of keratin is essential to establishing the epithelial origin of a given cell type or its tumor derivatives. Histologic tinctorial tests for keratin have not been widely applied because of lack of specificity and sensitivity. Rhodamine B fluorescence demonstrates well differentiated keratin in many epithelial cells and tumors. Immunocytochemical staining with broad range antibodies and epithelial membrane antigen demonstrates most epithelial moieties. By electron microscopy, the identification of tight junctions, desmosomes and tonofibrils helps establish the epithelial lineage of a tumor.
引用
收藏
页码:51 / 55
页数:5
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