Tailoring combinatorial cancer therapies to target the origins of adaptive resistance

被引：8
|
作者：
Goldman, Aaron [1 ]
机构：
[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Biomed Engn, Cambridge, MA 02115 USA
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2016年 / 3卷 / 01期
关键词：
adaptive resistance; tumor heterogeneity; cancer stem cells; mathematical modeling; computational biology;
D O I：
10.1080/23723556.2015.1030534
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The development of resistance to chemotherapy is a critical yet poorly understood phenomenon driving cancer-related deaths. We recently reported a study that explored the origins of adaptive chemotherapy resistance. During this investigation we unexpectedly discovered that inherent vulnerabilities were unmasked, creating temporal targets for rational combinations of established drugs.
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页数：2
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