ENDOGENOUS-DIGITALIS-LIKE-FACTOR AS A STIMULATOR OF ENDOTHELIN SECRETION FROM ENDOTHELIAL-CELLS

被引：12
|
作者：
YAMADA, K
GOTO, A
HUI, C
SUGIMOTO, T
机构：
[1] The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 01期
关键词：
D O I：
10.1016/S0006-291X(05)80190-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Effects of human urine-derived endogenous digitalis-like factor (EDLF) and ouabain on endothelin (ET) secretion were examined in cultured endothelial cells. ET was secreted in a linear fashion over 5 hours from bovine pulmonary artery endothelium into serum-free medium. EDLF stimulated ET secretion in a dose-dependent manner. In contrast, ouabain did not affect ET secretion at the concentration of 10-9-10-5M. These results indicate that human urine-derived EDLF is distinct from plant-derived ouabain and act as a stimulator of ET secretion by endothelial cells. © 1990 Academic Press, Inc.
引用
收藏
页码：178 / 183
页数：6
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