FLUORO-DIDEUTERO-METHYL 1,1,1,3,3,3-HEXAFLUOROISOPROPYL ETHER (D-2-SEVOFLURANE) REACTIONS ON SODA LIME - DEUTERIUM CONTENT OF DEUTERATED SEVOFLURANE AND ITS VOLATILE DEGRADATION PRODUCTS

被引：5

作者：

RUZICKA, JA ^{[1
]}

BAKER, MT ^{[1
]}

机构：

[1] UNIV IOWA,DEPT ANESTHESIA,IOWA CITY,IA 52242

来源：

JOURNAL OF FLUORINE CHEMISTRY | 1995年 / 71卷 / 01期

关键词：

SEVOFLURANE; D-2-SEVOFLURANE; DEUTERATION; SODA LIME; DEGRADATION PRODUCTS;

D O I：

10.1016/0022-1139(94)03152-P

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The degradation of the experimental anesthetic, fluoro-dideutero-methyl 1,1,1,3,3,3-hexafluoroisopropyl ether (D-2-sevoflurane) on soda lime (Sodasorb((R))) has been compared with sevoflurane and examined in regard to product deuterium content. Similar products and rates of degradation were found between sevoflurane and D-2-sevoflurane, and all D-2-sevoflurane products contained the fluorodideuteromethoxy group. Four products contained a trideuteromethoxy moiety, indicating the addition of methanol derived from the fluoromethoxy carbon of D-2-sevoflurane.

引用

页码：55 / 58

页数：4

共 6 条

[1] Fluoro-dideutero-methyl 1,1,1,3,3,3-hexafluoroisopropyl ether (D2-sevoflurane) reactions on soda lime: deuterium content of deuterated sevoflurane and its volatile degradation products
Ruzicka, J. A.
Baker, M. T.
Journal of Fluorine Chemistry, 71 (01):
[2] SYNTHESIS OF FLUORO-DIDEUTERO-METHYL 1,1,1,3,3,3-HEXAFLUORO-2-PROPYL ETHER (DEUTERATED SEVOFLURANE)
BAKER, MT
CHIANG, CK
TINKER, JH
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1993, 33 (09): : 801 - 807
[3] Deuterium labeling of methyl 1,1,1,3,3,3-hexafluoroisopropyl ether
Baker, MT
Ronnenberg, WC
Ruzicka, JA
Tinker, JH
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1997, 39 (05): : 387 - 393
[4] Deuterium labeling of methyl 1,1,1,3,3,3-hexafluoroisopropyl ether
Department of Anesthesia, University of Iowa, Iowa City, IA 52242, United States
不详
Journal of Labelled Compounds and Radiopharmaceuticals, 1997, 39 (05): : 387 - 393
[5] DETAILED INVESTIGATION OF FLUOROMETHYL 1,1,1,3,3,3-HEXAFLUORO-2-PROPYL ETHER (SEVOFLURANE) AND ITS DEGRADATION PRODUCTS .1. SYNTHESIS OF FLUORINATED, SODA LIME INDUCED DEGRADATION PRODUCTS
HUANG, CL
VENTURELLA, VS
CHOLLI, AL
VENUTOLO, FM
SILBERMANN, AT
VERNICE, GG
JOURNAL OF FLUORINE CHEMISTRY, 1989, 45 (02) : 239 - 253
[6] DETAILED INVESTIGATION OF FLUOROMETHYL 1,1,1,3,3,3-HEXAFLUORO-2-PROPYL ETHER (SEVOFLURANE) AND ITS DEGRADATION PRODUCTS .2. TWO-DIMENSIONAL F-19 NMR CHARACTERIZATION OF FLUOROMETHYL 1,1,3,3,3-PENTAFLUORO-2-PROPENYL ETHER
CHOLLI, AL
HUANG, C
VENTURELLA, V
PENNINO, DJ
VERNICE, GG
APPLIED SPECTROSCOPY, 1989, 43 (01) : 24 - 27

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