THE COMPLETE DNA-SEQUENCE OF YEAST CHROMOSOME-III

被引：731

作者：

OLIVER, SG

VANDERAART, QJM

AGOSTONI-CARBONE, ML

AIGLE, M

ALBERGHINA, L

ALEXANDRAKI, D

ANTOINE, G

ANWAR, R

BALLESTA, JPG

BENIT, P

BERBEN, G

BERGANTINO, E

BITEAU, N

BOLLE, PA

BOLOTINFUKUHARA, M

BROWN, A

BROWN, AJP

BUHLER, JM

CARCANO, C

CARIGNANI, G

CEDERBERG, H

CHANET, R

CONTRERAS, R

CROUZET, M

DAIGNANFORNIER, B

DEFOOR, E

DELGADO, M

DEMOLDER, J

DOIRA, C

DUBOIS, E

DUJON, B

DUSTERHOFT, A

ERDMANN, D

ESTEBAN, M

FABRE, F

FAIRHEAD, C

FAYE, G

FELDMANN, H

FIERS, W

FRANCINGUESGAILLARD, MC

FRANCO, L

FRONTALI, L

FUKUHARA, H

FULLER, LJ

GALLAND, P

GENT, ME

GIGOT, D

GILLIQUET, V

GLANSDORFF, N

GOFFEAU, A

机构：

[1] LEIDEN UNIV, DEPT CELL BIOL GENET, NL-2300 RA LEIDEN, NETHERLANDS

[2] UNIV MILAN, DIPARTIMENTO GENET & BIOL MICROORGANISMI, I-20122 MILAN, ITALY

[3] LBMS, F-33000 BORDEAUX, FRANCE

[4] UNIV MILAN, DIPARTIMENTO FISIOL & BIOCHIM, I-20122 MILAN, ITALY

[5] INST MOLEC BIOL & BIOTECHNOL, GR-71110 IRAKLION, GREECE

[6] CTR UNIV ORSAY, INST CURIE, F-91405 ORSAY, FRANCE

[7] CTR BIOL MOLEC, E-28049 MADRID, SPAIN

[8] FAC SCI AGRON ETAT GEMBLOUX, B-5030 GEMBLOUX, BELGIUM

[9] DIPARTIMENTO CHIM BIOL, I-35100 PADUA, ITALY

[10] UNIV PARIS 11, INST GENET & MICROBIOL, F-91405 ORSAY, FRANCE

[11] UNIV ABERDEEN, DEPT MOLEC & CELL BIOL, ABERDEEN AB9 1FX, SCOTLAND

[12] CENS, SERV BIOCHIM, F-91191 GIF SUR YVETTE, FRANCE

[13] INST MICROBIOL, W-6100 DARMSTADT, GERMANY

[14] LAB MOLEC BIOL, B-9000 GHENT, BELGIUM

[15] KATHOLIEKE UNIV LEUVEN, GENTECHNOL LAB, B-3001 LOUVAIN, BELGIUM

[16] LA CRUZ DEL CAMPO SA, E-41080 SEVILLE, SPAIN

[17] CTR ENSEIGNEMENT & RECH IND ALIMENTAIRES & CHIM, COOVI, RES INST, B-1070 BRUSSELS, BELGIUM

[18] INST PASTEUR, F-75724 PARIS 15, FRANCE

[19] UNIV GIESSEN, INST MIKROBIOL & MOLEK BIOL, W-6300 GIESSEN, GERMANY

[20] UNIV MUNICH, INST PHYSIOL CHEM, W-8000 MUNICH 2, GERMANY

[21] UNIV ROME, DEPT CELL & DEV BIOL, I-00185 ROME, ITALY

[22] INST FOOD RES, NORWICH NR4 7UA, NORFOLK, ENGLAND

[23] CATHOLIC UNIV LOUVAIN, UNITE BIOCHIM PHYSIOL, B-1348 LOUVAIN, BELGIUM

[24] UNIV LIBRE BRUXELLES, CELL PHYSIOL & YEAST GENET LAB, B-1050 BRUSSELS, BELGIUM

[25] UNIV AMSTERDAM, MOLEC BIOL SECT, 1098 SM AMSTERDAM, NETHERLANDS

[26] MARTINSRIED INST PROT SEQUENCES, W-8033 MARTINSRIED, GERMANY

[27] ECOLE NORM SUPER, F-75231 PARIS 05, FRANCE

[28] CNRS, CTR GENET MOLEC, F-91190 GIF SUR YVETTE, FRANCE

[29] UNIV DUSSELDORF, INST MIKROBIOL, W-4000 DUSSELDORF 1, GERMANY

[30] KOBE UNIV, DEPT BIOL, KOBE 657, JAPAN

[31] UNIV DUBLIN TRINITY COLL, DEPT GENET, DUBLIN 2, IRELAND

[32] FREE UNIV AMSTERDAM, DEPT BIOCHEM & MOLEC BIOL, 1081 HV AMSTERDAM, NETHERLANDS

[33] UNIV MED & DENT NEW JERSEY, NEW JERSEY MED SCH, DEPT MICROBIOL & MOLEC GENET, NEWARK, NJ 07103 USA

[34] UNIV CONSTANCE, FAK BIOL, W-7750 CONSTANCE, GERMANY

[35] CARLSBERG LAB, DK-2500 COPENHAGEN, DENMARK

[36] COMMISS EUROPEAN COMMUNITIES, B-1049 BRUSSELS, BELGIUM

来源：

NATURE | 1992年 / 357卷 / 6373期

关键词：

D O I：

10.1038/357038a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The entire DNA sequence of chromosome III of the yeast Saccharomyces cerevisiae has been determined. This is the first complete sequence analysis of an entire chromosome from any organism. The 315-kilobase sequence reveals 182 open reading frames for proteins longer than 100 amino acids, of which 37 correspond to known genes and 29 more show some similarity to sequences in databases. Of 55 new open reading frames analysed by gene disruption, three are essential genes; of 42 non-essential genes that were tested, 14 show some discernible effect on phenotype and the remaining 28 have no overt function.

引用

页码：38 / 46

页数：9

共 51 条

[1] NUCLEOTIDE-SEQUENCE OF A 24,206-BASE-PAIR DNA FRAGMENT CARRYING THE ENTIRE NITROGEN-FIXATION GENE-CLUSTER OF KLEBSIELLA-PNEUMONIAE [J].