ASSOCIATION AND ACTIVATION OF BTK AND TEC TYROSINE KINASES BY GP130, A SIGNAL TRANSDUCER OF THE INTERLEUKIN-6 FAMILY OF CYTOKINES

被引:139
|
作者
MATSUDA, T
TAKAHASHITEZUKA, M
FUKADA, T
OKUYAMA, Y
FUJITANI, Y
TSUKADA, S
MANE, H
HIRAI, H
WITTE, ON
HIRANO, T
机构
[1] OSAKA UNIV, SCH MED, CTR BIOMED RES, DIV MOLEC ONCOL, SUITA, OSAKA 565, JAPAN
[2] UNIV CALIF LOS ANGELES, HOWARD HUGHES MED INST, DEPT MICROBIOL & MOLEC GENET, LOS ANGELES, CA 90024 USA
[3] JICHI MED SCH, DEPT MOLEC BIOL, KAWACHI, TOCHIGI, JAPAN
[4] UNIV TOKYO, FAC MED, DEPT INTERNAL MED 3, TOKYO 113, JAPAN
关键词
D O I
10.1182/blood.V85.3.627.bloodjournal853627
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Interleukin-8 (IL-6), leukemia inhibitory factor, oncostatin M, IL-11, and ciliary neurotrophic factor constitute the IL-6 family of cytokines and play important roles in hematopoiesis, immune response, and nervous system. The receptors for the IL-6 family of cytokines share gp130 through which signals are generated, although the cytoplasmic region of gp130 does not contain any catalytic domain. In this study we show that in addition to Jak family tyrosine kinase, the stimulation of gp130 by IL-6 plus soluble IL-6 receptor cu induced the activation of Btk and Tec tyrosine kinases, whereas IL-3 and granulocyte colony-stimulating factor activated Tec but not Btk in a pro-B cell line. Furthermore, both Btk and Tec kinases were associated with gp130 without the ligand stimulation. Because Btk is a critical tyrosine kinase for B lymphopoiesis and Tec is considered to be involved in hematopoiesis. the results suggest the involvement of gp130-Btk-Tec signal pathway in early lymphohematopoiesis. (C) 1995 by The American Society of Hematology.
引用
收藏
页码:627 / 633
页数:7
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