CYTOTOXIC-CELLS BY HYBRIDIZATION IN-SITU AND IMMUNOHISTOCHEMISTRY IN MUSCLE-TISSUE BIOPSIES FOR POLYMYOSITIS AND DERMATOMYOSITIS

被引：0
|
作者：
CHERIN, P
CREVON, MC
HAUW, JJ
GALANAUD, P
HERSON, S
EMILIE, D
机构：
[1] Service de Médecine Interne, Hôpital de la Salpêtrière, 75651 PARIS Cédex 13, 47, boulevard de l'Hôpital
[2] Unité INSERM, U 131 d'Immunologie et Immunopathologie virale, 92140 CLAMART, 132, rue des Carnets
[3] Service de Neuropathologie, Hôpital de la Salpêtrière, 75651 PARIS Cédex 13, 47, boulevard de l'Hôpital
来源：
REVUE DE MEDECINE INTERNE | 1993年 / 14卷 / 06期
关键词：
D O I：
10.1016/S0248-8663(05)80427-8
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cytotoxic cells can kill target cells by secretion of several proteases, serine esterase B (SE-B), perforin (PF) and protein TIA-1. We analysed the presence of cytotoxic cells expressing the SE-B and PF genes by in situ hybridization and expression of TIA-1 by immunohistochimical study from muscular biopsies of 13 patients with inflammatory myopathies ; compared to those from 11 subjects control. We found expression of PF in 9 patients, SE-B gene in 10 and liberation of TIA-1 in 12 out of the 13 muscular biopsies tested, supporting the role of cytotoxic cells in pathogeny of inflammatory myopathies.
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页码：493 / 493
页数：1
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