EFFECT OF RADIATION COMBINED WITH HYPERTHERMIA ON HUMAN PROSTATIC-CARCINOMA CELL-LINES IN CULTURE

被引：8
|
作者：
KAVER, I
WARE, JL
WILSON, JD
KOONTZ, WW
机构：
[1] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PATHOL,DIV UROL,RICHMOND,VA 23298
[2] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT RADIOL,DIV UROL,RICHMOND,VA 23298
来源：
UROLOGY | 1991年 / 38卷 / 01期
关键词：
D O I：
10.1016/0090-4295(91)80025-3
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The effect of radiation combined with heat on three human prostatic carcinoma cell lines growing in vitro was investigated. Cells were exposed to different radiation doses followed by heat treatment at 43-degrees-C for one hour. Heat treatment, given ten minutes after radiation, significantly enhanced the radiation response of all the cell lines studied. The combined effect of radiation and heat produced greater cytotoxicity than predicted from the additive effects of the two individual treatment modalities alone. These results indicate that a combined treatment regimen of radiation plus hyperthermia (43-degrees, 1 hr) might be an important tool in maintaining a better local control of prostatic cancer.
引用
收藏
页码：88 / 92
页数：5
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