QUANTIFICATION OF INFLAMMATORY BOWEL-DISEASE ACTIVITY USING TC-99M HMPAO LABELED LEUKOCYTE SINGLE-PHOTON EMISSION COMPUTERIZED-TOMOGRAPHY (SPECT)

被引:37
|
作者
WELDON, MJ
MASOOMI, AM
BRITTEN, AJ
GANE, J
FINLAYSON, CJ
JOSEPH, AEA
MAXWELL, JD
机构
[1] ST GEORGE HOSP,DEPT RADIOL,LONDON SW17 0RE,ENGLAND
[2] ST GEORGE HOSP,DEPT MED PHYS,LONDON SW17 0RE,ENGLAND
[3] ST GEORGE HOSP,DEPT HISTOPATHOL,LONDON SW17 0RE,ENGLAND
[4] UNIV LONDON SCH MED,LONDON,ENGLAND
关键词
INFLAMMATORY BOWEL DISEASE; TC-99M; SINGLE PHOTON EMISSION COMPUTERIZED TOMOGRAPHY;
D O I
10.1136/gut.36.2.243
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Technetium-99m HMPAO labelled white cell bowel uptake was quantified in 23 patients with suspected colitis by means of the novel technique of single photon emission computerised tomography (SPECT) using a standard gamma-camera. Uptake in colon segments was quantified on transaxial images and expressed as a fraction of marrow uptake (SPECT score). Segmental histological disease activity was assessed at (20) or at surgery (3). histology score with SPECT score r=0.79 Overall SPECT score for all affected segments correlated with Crohn's disease activity index (CDAI) r=0.66, p=0.001 and with laboratory activity indices; erythrocyte sedimentation rate p=0.03, C reactive protein r=0.38, p=0.05, and albumin r=-0.46, p=0.03. Small bowel SPECT score in 13 patients correlated with CDAI r=0.65, p<0.01 but not with erythrocyte sedimentation rate or C reactive protein. Five patients with positive small bowel white cell uptake had normal C reactive protein and erythrocyte sedimentation rate. Overall SPECT score for disease at all sites correlated with both CDAI and with laboratory indices of inflammation. Tc-99m HMPAO SPECT provides non-invasive and accurate quantification of inflammatory bowel disease activity in both large and small bowel and may be useful in the objective evaluation of treatment for inflammatory bowel disease.
引用
收藏
页码:243 / 250
页数:8
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