HEPATITIS-C VIRUS-REPLICATION IN AUTOIMMUNE CHRONIC HEPATITIS

被引:75
|
作者
MAGRIN, S
CRAXI, A
FABIANO, C
FIORENTINO, G
ALMASIO, P
PALAZZO, U
PINZELLO, G
PROVENZANO, G
PAGLIARO, L
CHOO, QL
KUO, G
POLITO, A
HAN, J
HOUGHTON, M
机构
[1] UNIV PALERMO,MED CLIN R,I-90134 PALERMO,ITALY
[2] CHIRON CORP,EMERYVILLE,CA
关键词
D O I
10.1016/0168-8278(91)90082-M
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Both high and low anti-hepatitis C virus antibody (anti-HCV) prevalence has been reported in autoimmune chronic active hepatitis. Therefore, we studied 15 consecutive HBsAg-negative, ELISA anti-HCV-positive, autoantibody-positive patients with biopsy proven chronic active hepatitis in order to confirm ELISA specificity by immunoblot test (RIBA-HCV), and to evaluate HCV replication by serum HCV-RNA. Nine patients were anti-nuclear, three type 1 anti-liver-kidney microsomal and three anti-smooth muscle antibody positive. None had associated autoimmune disease. All cases showed mild clinical disease and only moderate necroinflammatory activity. Response to prednisone was poor. RIBA-HCV confirmed ELISA results in all patients. HCV-RNA was found in the serum from 10 patients. Institution of alpha-interferon treatment in three steroid non-responsive patients was followed by prompt normalization of transaminases. Thus, a subgroup of autoantibody-positive chronic active hepatitis can be recognized as HCV-related and should be clinically and etiologically distinguished from autoimmune chronic active hepatitis. Trials of alpha-interferon treatment are worthwhile in this condition.
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收藏
页码:364 / 367
页数:4
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