SYNTHESIS AND PHARMACOLOGICAL ACTIVITIES OF CALCIUM MODULATORY HEXAHYDROQUINOLINONES

被引：0
|
作者：
ROSE, U
机构：
来源：
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH | 1991年 / 41-1卷 / 03期
关键词：
CALCIUM ANTAGONISTS; HEXAHYDROQUINOLINONES; PHARMACOLOGY; SYNTHESIS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Hexahydroquinolinones of type 6 are accessible from Hantzsch-like cyclization of 1,3-cyclohexanedione with aromatic aldehydes and different beta-aminocrotonates and acetoacetates/ammonia, respectively. Reaction with pyridiniumbromideperbromide leads to the octahydrofuro[3,4-b] quinoline-diones 6h and 6i. 6j was obtained by N-alkylation. Positive inotropic effects were observed on electrically stimulated left atria of guinea pigs whereas BaCl2-induced contractions of the ileum were inhibited in a dose dependent manner. On electrically stimulated guinea pig papillary muscle 6h exhibits contractility promoting effects which can be attributed to calcium agonism.
引用
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页码：199 / 203
页数：5
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