UPDATE OF THE TOPICAL TREATMENT OF PSORIASIS

被引：23

作者：

Carrascosa, J. M. ^{[1
]}

Vanaclocha, F. ^{[2
]}

Borrego, L. ^{[3
]}

Fernandez-Lopez, E. ^{[4
]}

Fuertes, A. ^{[5
]}

Rodriguez-Fernandez-Freire, L. ^{[6
]}

Zulaica, A. ^{[7
]}

Tuneu, A. ^{[8
]}

Caballe, G. ^{[9
]}

Colome, E. ^{[9
]}

Bordas, X. ^{[10
]}

Hernanz, J. M. ^{[11
]}

Brufau, C. ^{[12
]}

Herrera, E. ^{[13
]}

机构：

[1] Hosp Badalona Germans Trias & Pujol, Serv Dermatol, Barcelona 08916, Spain

[2] Hosp 12 Octubre, Serv Dermatol, Madrid, Spain

[3] Hosp Univ Insular Gran Canaria, Las Palmas Gran Canaria, Spain

[4] Hosp Univ Salamanca, Serv Dermatol, Salamanca, Spain

[5] Hosp Univ Dr Peset, Serv Dermatol, Valencia, Spain

[6] Hosp Univ Sevilla, Serv Dermatol, Seville, Spain

[7] Complejo Hosp Univ Vigo, Serv Dermatol, Vigo, Spain

[8] Hosp Donostia San Sebastian, San Sebastian, Spain

[9] LEO Pharma, Barcelona, Spain

[10] Ciutat Univ Bellvitge, Barcelona, Spain

[11] Hosp Infanta Leonor, Secc Dermatol, Madrid, Spain

[12] Hosp Gen Univ Reina Sofia, Secc Dermatol, Murcia, Spain

[13] Hosp Clin, Secc Dermatol, Malaga, Spain

来源：

ACTAS DERMO-SIFILIOGRAFICAS | 2009年 / 100卷 / 03期

关键词：

psoriasis; topical treatment; therapy;

D O I：

10.1016/S0001-7310(09)70534-4

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Topical therapy continues to be one of the pillars of psoriasis management. Topical corticosteroids and vitamin D analogs are the drugs of choice during the induction phase, and vitamin D analogs continue to be drugs of choice for maintenance therapy. Tazarotene and dithranol are suitable options in patients with certain, specific characteristics. The calcineurin inhibitors can be considered to be second-line treatment for psoriasis of the face and flexures. The efficacy and safety of the fixed-dose combination of betamethasone and calcipotriol in the induction phase is greater than that of either drug alone. The combination of corticosteroids with salicylic acid achieves better results than corticosteroids in monotherapy. None of the drugs evaluated stands out over the others in all clinical situations, and their use must therefore be individualized in each patient and adjusted according to the course of the disease.

引用

页码：190 / 200

页数：11

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