STUDY OF THE ANTIGENIC STRUCTURE OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS GLYCOPROTEIN-E2 USING RAT MONOCLONAL-ANTIBODIES

被引:0
|
作者
RAZUMOV, IA [1 ]
AGAPOV, EV [1 ]
PEREBOEV, AV [1 ]
PROTOPOPOVA, EV [1 ]
LEBEDEVA, SD [1 ]
LOKTEV, VB [1 ]
机构
[1] VEKTOR SCI IND ASSOC,KOLTSOV,USSR
关键词
D O I
暂无
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
A collection of 21 rat hybridomas secreting highly affinic monoclonal antibodies to Venezuelan equine encephalomyelitis (VEE) virus was generated. Using a panel of 15 monoclonal antibodies to glycoprotein E2, the antigenic structure of this protein of VEE strains TC-83 and 230 was studied. A competitive radioimmunoassay suggested a new map of the antigenic structure of glycoprotein E2 in which 5 sites including 11 epitopes of monoclonal antibody binding were distinguished. Antibody to E2-2 site neutralized virus infectivity and blocked hemagglutination test and antibody to E2-3 site could only block hemagglutination. Antibodies to other E2 protein sites lacked any biological activity.
引用
收藏
页码:34 / 37
页数:4
相关论文
共 50 条
  • [1] ANTIGENIC VARIANTS OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS SELECTED WITH NEUTRALIZING MONOCLONAL-ANTIBODIES
    AGAPOV, YV
    LEBEDEVA, SD
    RAZUMOV, IA
    FROLOV, IV
    KOLYKHALOV, AA
    LOKTEV, VB
    NETESOV, SV
    SANDAKHCHIYEV, LS
    DOKLADY AKADEMII NAUK SSSR, 1991, 320 (06): : 1485 - 1488
  • [2] STUDY OF RECEPTOR REGION OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS USING MONOCLONAL-ANTIBODIES
    RAZUMOV, IA
    PEREBOEV, AV
    PROTOPOPOVA, EV
    KHUSAINOVA, AD
    AGAPOV, EV
    MELNIKOVA, EE
    GAIDAMOVICH, SY
    LOKTEV, VB
    VOPROSY VIRUSOLOGII, 1991, 36 (06) : 489 - 492
  • [3] INVESTIGATION OF EASTERN EQUINE ENCEPHALOMYELITIS VIRUS ANTIGENIC STRUCTURE USING MONOCLONAL-ANTIBODIES
    PEREBOEV, AV
    AGAPOV, EV
    SVYATCHENKO, VA
    RAZUMOV, IA
    PROTOPOPOVA, EV
    LOKTEV, VB
    VOPROSY VIRUSOLOGII, 1993, 38 (03) : 117 - 122
  • [4] ANTIGENIC ANALYSIS OF THE SURFACE GLYCOPROTEINS OF A VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS (TC-83) USING MONOCLONAL-ANTIBODIES
    ROEHRIG, JT
    DAY, JW
    KINNEY, RM
    VIROLOGY, 1982, 118 (02) : 269 - 278
  • [5] BIOLOGICAL AND IMMUNOCHEMICAL PROPERTIES OF MONOCLONAL-ANTIBODIES TO VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS
    SHPILEVAJA, MV
    TUGHIZOV, SM
    KUSCH, AA
    TSILINSKY, YY
    MAKAROVA, NE
    VOPROSY VIRUSOLOGII, 1991, 36 (06) : 495 - 498
  • [6] EPITOPE SPECIFICITY AND PROTECTIVE ACTIVITY OF MONOCLONAL-ANTIBODIES TO VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS
    SHPILEVAYA, MV
    KUSCH, AA
    RAZUMOV, IA
    ARKHIPOV, VN
    TSLINSKY, YY
    LOKTEV, VB
    VOPROSY VIRUSOLOGII, 1995, 40 (02) : 82 - 85
  • [7] USE OF MONOCLONAL-ANTIBODIES TO CHARACTERIZE THE ENVELOPE GLYCOPROTEIN-E2 OF SEMLIKI FOREST VIRUS (SFV)
    WALTER, G
    KALUZA, G
    ZENTRALBLATT FUR BAKTERIOLOGIE MIKROBIOLOGIE UND HYGIENE SERIES A-MEDICAL MICROBIOLOGY INFECTIOUS DISEASES VIROLOGY PARASITOLOGY, 1984, 257 (01): : 165 - 165
  • [8] THE PROPERTIES OF MAK-14-7 MONOCLONAL-ANTIBODIES TO VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS
    GAIDAMOVICH, SJ
    NOVOKHATSKII, AS
    MELNIKOVA, EE
    KUSHCH, AA
    SVESHNIKOVA, NA
    ZHDANOV, VM
    DOKLADY AKADEMII NAUK SSSR, 1982, 267 (02): : 466 - 468
  • [9] INVESTIGATION OF THE ANTIGENIC STRUCTURE OF RABIES VIRUS GLYCOPROTEIN BY MONOCLONAL-ANTIBODIES
    LAFON, M
    IDELER, J
    WUNNER, WH
    DEVELOPMENTS IN BIOLOGICALS, 1984, 57 : 219 - 225
  • [10] Monoclonal idiotypic antibodies mimicking the hemagglutination activity domain of E2 glycoprotein of Venezuelan equine encephalomyelitis (VEE) virus.
    Lifke, VV
    Razumov, IA
    Konovalova, SN
    VOPROSY VIRUSOLOGII, 1997, 42 (01) : 19 - 23