NATURALLY-OCCURRING AGE-DEPENDENT GLUTATHIONE-S-TRANSFERASE-PI IMMUNOREACTIVE HEPATOCYTES IN AGING FEMALE F344 RAT-LIVER AS POTENTIAL PROMOTABLE TARGETS FOR NONGENOTOXIC CARCINOGENS

被引：28

作者：

WARD, JM ^{[1
]}

HENNEMAN, JR ^{[1
]}

机构：

[1] NCI, FREDERICK CANC RES FACIL, PROGRAM RESOURCES INC, BIOL CARCINOGENESIS & DEV PROGRAM, FREDERICK, MD 21701 USA

来源：

CANCER LETTERS | 1990年 / 52卷 / 03期

关键词：

F344; rat; glutathione S-transferase; placental form; non-genotoxic carcinogens; phenobarbital; rat liver;

D O I：

10.1016/0304-3835(90)90186-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Naturally occurring basophilic foci (focal hepatocellular proliferative lesions) (FHPL) in the livers of aging female F344 NCr rats could not be promoted to grow or progress into tumors after phenobarbital (PB) exposure. Instead, PB induced new unique eosinophilic hepatocellular foci and adenomas much quicker in old rats than in young rats. We now report that these foci are immunoreactive for glutathione S-transferase π (GSTP) and that they appear to arise from some naturally occurring single and double GSTP-reactive cells and foci which occur spontaneously in the liver of aging F344 rats in an age-related fashion. PB and other nongenotoxic chemicals may act as "carcinogens" by promoting the growth (clonal expansion) of some of these putative spontaneously-initiated cells and foci into tumors. © 1990.

引用

页码：187 / 195

页数：9