Functional Activity Of Vascular Hemostasis In Newborn Calves With Iron Deficiency

Currently, iron deficiency anemia is still a common condition in newborn calves, resulting in inhibition of their growth and development processes and often in death of the animal. The processes of hemestasis sensitively respond to changes in the external environment and the state of the body of the calf, sometimes forming a to tendency to thrombosis. The occurrence of anemia in calves inevitably weakens their growing boar, affecting the Abs e otthe vascular wall. In the anemized animals included in the study, a decrease In the Index of antiaggref 2 ylactivity of the vascular wall with all Inducers and their combinations was noted. The indices of the antia tegatery activity of the vascular wall with the combination of inductors turned out to be the lowest. In thAltase of -isolated use of aggregation inducers, the lowest index of entlaggregatorylectivity of the vascular vve:.iwith collagen was found due to the weakest inhibition of platelet aggregation with:this inducer . during ven tZsion. A slightly higher level of the index of antiaggregatory activity of the vascular wall Is registeredetith adrenaline and thrombin. They.were superior to the index of anti-aggregation activity of the vascular wall with ADP (1.45 +/- 0.12) Anil rfotonsYcin (1.4 +/-.05), else, ree4bly yielding to control. In the blood of ncnybdrn calves with iron deficiency, depression of tirund isal level of antithrombin III was noted by 17.6%. This was'accompanied by a,decrease In their production, ntithrornbin III by endothellocytes, which led to a decrease in its stimulated level In blood plasma, forming' . the body an obvious deficiency of anticoagulants of vascular origin. It can be considered that In newborn calves with iron deficiency, activated lipid peroxidatlon In the blood plasma contributes to the weakening of the hemostatic activity of the vascular wall, creating the basis for hemostasiopathy.