A CONVENIENT SYNTHESIS OF CHIRAL OXAZOLIDIN-2-ONES AND THIAZOLIDIN-2-ONES AND AN IMPROVED PREPARATION OF TRIPHOSGENE

被引：30
|
作者：
FALB, E [1 ]
NUDELMAN, A [1 ]
HASSNER, A [1 ]
机构：
[1] BAR ILAN UNIV,DEPT CHEM,IL-52900 RAMAT GAN,ISRAEL
来源：
SYNTHETIC COMMUNICATIONS | 1993年 / 23卷 / 20期
关键词：
D O I：
10.1080/00397919308012605
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Oxazolidin-2-ones and thiazolidin-2-one are conveniently prepared by condensation of L-serine, L-threonine and L-cysteine, respectively with triphosgene. The corresponding methyl esters may be subsequently obtained by quenching the reaction mixture with methanol, without prior need for the isolation of the free acids. An improved procedure for preparation of triphosgene using an internal cooling system is described.
引用
收藏
页码：2839 / 2844
页数：6
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