LOCALIZATION OF THE GENE ENCODING INSULIN-DEGRADING ENZYME TO HUMAN CHROMOSOME-10, BANDS Q23-]Q25

被引：15
|
作者：
ESPINOSA, R
LEMONS, RS
PERLMAN, RK
KUO, WL
ROSNER, MR
LEBEAU, MM
机构：
[1] UNIV CHICAGO,MED CTR,DEPT MED,HEMATOL ONCOL SECT,5841 S MARYLAND AVE,BOX 420,CHICAGO,IL 60637
[2] UNIV UTAH,DEPT PEDIAT,SALT LAKE CITY,UT 84112
[3] UNIV CHICAGO,BEN MAY INST,CHICAGO,IL 60637
[4] UNIV CHICAGO,DEPT PHARMACOL & PHYSIOL SCI,CHICAGO,IL 60637
[5] UNIV CHICAGO,DEPT MOLEC GENET & CELL BIOL,CHICAGO,IL 60637
来源：
CYTOGENETICS AND CELL GENETICS | 1991年 / 57卷 / 04期
关键词：
D O I：
10.1159/000133142
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Insulin-degrading enzyme (IDE) is a cytosolic proteinase involved in the cellular processing of insulin. Using somatic cell hybrid analysis and in situ chromosomal hybridization, we have localized the gene encoding IDE to human chromosome 10, bands q23 --> q25. The murine Ide gene was previously mapped to Chromosome 19; together, these results suggest that the IDE gene is a member of a conserved syntenic group on human chromosome 10, bands q23 --> q25 and mouse Chromosome 19.
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页码：184 / 186
页数：3
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