ANTITHROMBOTIC EFFECT OF ARGATROBAN ON THE PIAL VESSELS OF THE RAT - A STUDY WITH HE-NE LASER-INDUCED THROMBUS FORMATION

被引：0

作者：

SASAKI, Y ^{[1
]}

MORII, S ^{[1
]}

YAMASHITA, T ^{[1
]}

YAMAMOTO, J ^{[1
]}

机构：

[1] KITASATO UNIV,SCH MED,DEPT NEUROSURG,SAGAMIHARA,KANAGAWA 228,JAPAN

来源：

HAEMOSTASIS | 1993年 / 23卷 / 02期

关键词：

ARGATROBAN; HE-NE LASER; PIAL VESSELS; CLOSED CRANIAL WINDOW TECHNIQUE;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The antithrombotic effect of the synthetic thrombin inhibitor (2R,4R)-4-methyl-1-[N2-(3-methyl-1,2,3,4-tetrahydro-8-quin-olinesulfonyl)-L-arginyl]-2-piperidinecarboxylic acid monohydrate (argatroban) was investigated in cerebral vessels of the rat. An occlusive thrombus was formed in pial vessels using a He-Ne laser in a closed cranial window technique. Argatroban retarded the formation of thrombi in a dose-dependent manner. The antithrombotic effect of a single intravenous dose of argatroban at 0.5 mg/kg was diminished after 30 min in arterioles and after 50 min in venules, respectively. The antithrombotic activity was maintained, however, by continuous intravenous infusion (2 mg/kg/h).

引用

页码：104 / 111

页数：8

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