INVOLVEMENT OF EXTERNAL CALCIUM IN THE RELEASE OF ARACHIDONIC-ACID BY MOUSE PERITONEAL-MACROPHAGES

被引：13
|
作者：
FERNANDEZ, B
BALSINDE, J
机构：
[1] CSIC,CTR INVEST BIOL,VELAZQUEZ 144,E-28006 MADRID,SPAIN
[2] HOSP 12 OCTUBRE,CTR INVEST,MADRID,SPAIN
来源：
FEBS LETTERS | 1990年 / 268卷 / 01期
关键词：
Arachidonic acid; Calcium influx; Mouse macrophage; Phospholipase A[!sub]2[!/sub;
D O I：
10.1016/0014-5793(90)80984-Q
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The present investigation was undertaken to study the potential role of extracellular calcium on the release of arachidonic acid from mouse peritoneal macrophages. Both in phorbol ester-treated and in Ca2+-depleted cells, a rapid release of arachidonic acid was seen in direct response to added Ca2+. The response was directly dependent on the extracellular Ca2+concentration, with a Ca2+ threshold of 100 nM. These results support the notion that arachidonic acid release in macrophages is functionally coupled to influx of external calcium. © 1990.
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页码：107 / 109
页数：3
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