INTEGRIN STIMULATION DECREASES TYROSINE PHOSPHORYLATION AND ACTIVITY OF FOCAL ADHESION KINASE IN THYMOCYTES

被引：9

作者：

KANAZAWA, S

ILIC, D

NOUMURA, T

YAMAMOTO, T

AIZAWA, S

机构：

[1] KUMAMOTO UNIV,SCH MED,IMEG,DEPT MORPHOGENESIS,KUMAMOTO 860,JAPAN

[2] SAITAMA UNIV,GRAD SCH SCI & ENGN,URAWA,SAITAMA 338,JAPAN

[3] UNIV TOKYO,INST MED SCI,DEPT ONCOL,MINATO KU,TOKYO 108,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 215卷 / 02期

关键词：

D O I：

10.1006/bbrc.1995.2484

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

FAK, focal adhesion kinase, is expressed in a variety of cell types and has been suggested to transduce signals brought about by integrin-extracellular matrix (ECM) interactions, Integrin stimulation increases tyrosine phosphorylation and activity of FAK in all the cells examined to date. In contrast, in thymocytes stimulation of VLA-4 (alpha(4) beta(1)) and LFA-1 (alpha(L) beta(2)) resulted in a marked decrease in tyrosine phosphorylation and activity of FAK. (C) 1995 Academic Press, Inc.

引用

页码：438 / 445

页数：8

共 50 条

[1] CELL-ADHESION OR INTEGRIN CLUSTERING INCREASES PHOSPHORYLATION OF A FOCAL ADHESION-ASSOCIATED TYROSINE KINASE
KORNBERG, L
EARP, HS
PARSONS, JT
SCHALLER, M
JULIANO, RL
JOURNAL OF BIOLOGICAL CHEMISTRY, 1992, 267 (33) : 23439 - 23442
[2] TYROSINE PHOSPHORYLATION OF FOCAL ADHESION KINASE IN MIGRATORY HUMAN KERATINOCYTES
YURKO, MA
OTOOLE, EA
WOODLEY, DT
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 105 (06) : 871 - 871
[3] Focal adhesion kinase is negatively regulated by phosphorylation at tyrosine 407
Lim, Yangmi
Park, Haein
Jeon, Jihyun
Han, Innoc
Kim, Jinsook
Jho, Eek-Hoon
Oh, Eok-Soo
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (14) : 10398 - 10404
[4] Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes
Oh, Min-A
Choi, Suyong
Lee, Mi Ji
Choi, Moon-Chang
Lee, Sin-Ae
Ko, Wonil
Cance, William G.
Oh, Eok-Soo
Buday, Laszlo
Kim, Sung-Hoon
Lee, Jung Weon
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2009, 1793 (05): : 781 - 791
[5] Phosphorylation of focal adhesion kinase (FAK) at tyrosine 407 and integrin β1 regulate NKCC cotransporter in Fundulus heteroclitus
Katoh, Fumi
Lynch, Briana N. G.
Cozzi, Regina R. F.
Marshall, William S.
FASEB JOURNAL, 2007, 21 (06): : A1337 - A1337
[6] An integrin (GpIIb/IIIa) independent phosphorylation of a novel related adhesion focal tyrosine kinase (RAFTK) in platelets.
Raja, S
Avraham, S
Avraham, H
BLOOD, 1996, 88 (10) : 80 - 80
[7] Minimal features of paxillin that are required for the tyrosine phosphorylation of focal adhesion kinase
Wade, R
Vande Pol, S
BIOCHEMICAL JOURNAL, 2006, 393 (565-573) : 565 - 573
[8] Cell density regulates tyrosine phosphorylation and localization of focal adhesion kinase
Xu, FP
Zhao, ZZJ
EXPERIMENTAL CELL RESEARCH, 2001, 262 (01) : 49 - 58
[9] The role of focal adhesion kinase tyrosine phosphorylation in rat hepatic fibrogenesis
Zhang, Xiaolan
Huo, Xiaoxia
Shen, Jiangang
Wei, Juan
An, Junyan
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2006, 21 : A374 - A374
[10] The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin
Thomas, JW
Cooley, MA
Broome, JM
Salgia, R
Griffin, JD
Lombardo, CR
Schaller, MD
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (51) : 36684 - 36692

← 1 2 3 4 5 →