THE HOX-5 AND SURFEIT GENE CLUSTERS ARE LINKED IN THE PROXIMAL PORTION OF MOUSE CHROMOSOME-2

被引：50

作者：

STUBBS, L

HUXLEY, C

HOGAN, B

EVANS, T

FRIED, M

DUBOULE, D

LEHRACH, H

机构：

[1] IMPERIAL CANC RES FUND,EUKARYOT GENE ORG,LONDON WC2A 3PX,ENGLAND

[2] IMPERIAL CANC RES FUND,EXPRESS LAB,LONDON WC2A 3PX,ENGLAND

[3] VANDERBILT UNIV,MED CTR,SCH MED,DEPT CELL BIOL,NASHVILLE,TN 37232

[4] EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANY

来源：

GENOMICS | 1990年 / 6卷 / 04期

关键词：

D O I：

10.1016/0888-7543(90)90499-K

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Using an interspecies backcross, we have mapped the HOX-5 and surfeit (surf) gene clusters within the proximal portion of mouse chromosome 2. While the HOX-5 cluster of homeobox-containing genes has been localized to chromosome 2, bands C3-E1, by in situ hybridization, its more precise position relative to the genes and cloned markers of chromosome 2 was not known. Surfeit, a tight cluster of at least six highly conserved "housekeeping" genes, has not been previously mapped in mouse, but has been localized to human chromosome 9q, a region of the human genome with strong homology to proximal mouse chromosome 2. The data presented here place HOX-5 in the vicinity of the closely linked set of developmental mutations rachiterata, lethargic, and fidget and place surf close to the proto-oncogene Abl, near the centromere of chromosome 2. © 1990.

引用

页码：645 / 650

页数：6

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