IMPAIRMENT OF MITOCHONDRIAL OXIDATIVE-PHOSPHORYLATION IN THE BRAIN OF AGED MICE

被引：76
|
作者：
FERRANDIZ, ML
MARTINEZ, M
DEJUAN, E
DIEZ, A
BUSTOS, G
MIQUEL, J
机构：
[1] UNIV ALICANTE, FAC MED, DEPT FARMACOL & TERAPEUT, E-03080 ALICANTE, SPAIN
[2] UNIV ALICANTE, FAC MED, INST NEUROCIENCIAS, E-03080 ALICANTE, SPAIN
[3] UNIV VALENCIA, FAC FARM, DEPT FARMACOL, E-46010 VALENCIA, SPAIN
来源：
BRAIN RESEARCH | 1994年 / 644卷 / 02期
关键词：
OXIDATIVE PHOSPHORYLATION; RESPIRATORY COMPLEX; MITOCHONDRION; BRAIN; AGING;
D O I：
10.1016/0006-8993(94)91699-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To elucidate the role of mitochondrial oxidative phosphorylation in neuronal aging, we have studied the activity of the respiratory complexes in the brain of young, adult and old mice. In synaptic mitochondria, we found a significant decrease in complexes IV (29%, P < 0.001) and V (21%, P < 0.01) in old as compared with adult mice. Nonsynaptic mitochondria also showed a senescent decrease in complexes I (15%, P < 0.01), II + III (34%, P < 0.01) and IV (17%, P < 0.01) activities. These findings suggest a dysfunction in mitochondrial oxidative phosphorylation in brain aging.
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页码：335 / 338
页数：4
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