IMPROVED PREPARATION OF L-[METHYL-C-11]METHIONINE BY ONLINE [C-11] METHYLATION

被引:15
|
作者
MIZUNO, KI [1 ]
YAMAZAKI, S [1 ]
IWATA, R [1 ]
PASCALI, C [1 ]
IDO, T [1 ]
机构
[1] TOHOKU UNIV,CYRIC,AOBA KU,SENDAI,MIYAGI 980,JAPAN
关键词
D O I
10.1016/0969-8043(93)90152-Z
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
On-line [C-11]methylation using [C-11]methyl iodide has been successfully applied to the preparation Of L-[Methyl-C-11]-methionine (C-11-Met). [C-11]Methyl iodide is first trapped in a short column that contains Porapak Q and L-homocysteine thiolactone coated on inert support. The column is then charged with NaOH dissolved in a mixture of ethanol and water to cause the [C-11]methylation. The present method can provide practically pure C-11-Met in radiochemical yield of over 98%. The whole procedure including the sterilization of final product has been completely automated for routine PET use.
引用
收藏
页码:788 / 790
页数:3
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