CALBISTRINS, NOVEL ANTIFUNGAL AGENTS PRODUCED BY PENICILLIUM-RESTRICTUM .2. ISOLATION AND ELUCIDATION OF STRUCTURE

被引：21
|
作者：
BRILL, GM
CHEN, RH
RASMUSSEN, RR
WHITTERN, DN
MCALPINE, JB
机构：
[1] Anti-infective Research, Abbott Laboratories, Abbott Park
来源：
JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 01期
关键词：
D O I：
10.7164/antibiotics.46.39
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The novel antifungal agents, calbistrins A, B, C and D have been isolated from a strain of Penicillium restrictum (AB 1875C-28). The four congeners were separated by bioactivity directed fractionation using countercurrent chromatography and preparative-HPLC. NMR studies revealed that the calbistrins each contain a carboxylic acid conjugated tetraene attached through an aliphatic ester linkage to a hexahydronaphthalene system.
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页码：39 / 47
页数：9
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