QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON BENZODIAZEPINE RECEPTOR-BINDING - INVESTIGATION OF INTERACTION-MODEL

被引：0

作者：

GUPTA, SP ^{[1
]}

MULCHANDANI, V ^{[1
]}

机构：

[1] BIRLA INST TECHNOL & SCI,DEPT PHARM,PILANI 333031,RAJASTHAN,INDIA

来源：

INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS | 1993年 / 30卷 / 03期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

With a view to providing perfection to the benzodiazepine receptor model proposed earlier [S P Gupta, R N Saha & V Mulchandani (1992) J. Mol Recog 5, 75-80] a few more QSAR studies on a series of 9-benzylpurines and tetracyclic 1,4-benzodiazepine derivatives have been made. The models showing the interaction of these compounds with the receptor are proposed. It is found that the receptor model, unlike the one proposed earlier, requires the presence of a polar site along with all the other essential sites.

引用

页码：181 / 186

页数：6

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