SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF TYRAMINE CONGENERS CONTAINING FUSED HETEROCYCLIC RINGS

被引：3
|
作者：
NORCINI, G
ALLIEVI, L
BERTOLINI, G
CASAGRANDE, C
MIRAGOLI, G
SANTANGELO, F
SEMERARO, C
机构：
[1] Zambon Group, Milan, Via Lillo del Duca, 10
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 28卷 / 06期
关键词：
ANTIHYPERTENSIVE AGENTS; TYRAMINE CONGENERS;
D O I：
10.1016/0223-5234(93)90018-A
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of tyramine congeners carrying a fused heterocyclic ring were synthesized with the aim of combining the positive inotropic effect of the cardiac phosphodiesterase III inhibitors with the vasodilatory effect of heterocyclic dopamine receptor agonists. None of the compounds showed the desired combination of properties. 2-Ethoxycarbonyl-4-(2-aminoethyl)-7-hydroxyindole 24 elicited a marked hypotensive effect in spontaneously hypertensive rats.
引用
收藏
页码：505 / 511
页数：7
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