ASCARIS-LUMBRICOIDES - DETECTING ITS METABOLITES IN THE URINE OF INFECTED PEOPLE USING GAS-LIQUID-CHROMATOGRAPHY

被引：7
|
作者：
HALL, A
ROMANOVA, T
机构：
来源：
EXPERIMENTAL PARASITOLOGY | 1990年 / 70卷 / 01期
关键词：
2-Methyl-butyramide; 2-Methyl-butyric acid; 2-Methyl-valeramide; 2-Methyl-valeric acid; Ascaris lumbricoides; Gas-liquid chromatography; Metabolites; urine; Nematode; parasitic;
D O I：
10.1016/0014-4894(90)90083-O
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Substances dissolved in the urine of people infected with Ascaris lumbricoides were extracted and detected by gas-liquid Chromatography. The ratios of the areas of the peaks produced by two substances extracted from urine to the area of the peak of solvent were found to be significantly correlated with the worm burden. A chemical analysis of the predominant substance by infrared spectrophotometry and proton magnetic resonance spectrometry indicated that it was 2-methyl-butyramide. The chemical properties of the other substance indicated that it was 2-methyl-valeramide. These substances are likely to be derivatives of two acids known to be end products of the carbohydrate metabolism of Ascaris. © 1990.
引用
收藏
页码：35 / 42
页数：8
相关论文
共 50 条
  • [1] QUANTITATION OF CYCLAZOCINE AND ITS METABOLITES IN HUMAN URINE BY USE OF GAS-LIQUID-CHROMATOGRAPHY
    KAIKO, RF
    INTURRISI, CE
    JOURNAL OF CHROMATOGRAPHY, 1974, 100 (01): : 63 - 72
  • [2] A GAS-LIQUID-CHROMATOGRAPHY ASSAY FOR PHENCYCLIDINE AND ITS METABOLITES
    KAMMERER, RC
    DISTEFANO, E
    SCHMITZ, D
    JOURNAL OF ANALYTICAL TOXICOLOGY, 1980, 4 (06) : 293 - 298
  • [3] DETERMINATION OF METOPROLOL METABOLITES IN PLASMA AND URINE BY ELECTRONCAPTURE GAS-LIQUID-CHROMATOGRAPHY
    QUARTERMAN, CP
    KENDALL, MJ
    JACK, DB
    JOURNAL OF CHROMATOGRAPHY, 1980, 183 (01): : 92 - 98
  • [4] INVESTIGATION OF THE ANTIGENS OF ASCARIS-LUMBRICOIDES USING A RADIOIMMUNOASSAY AND SERA OF NATURALLY INFECTED HUMANS
    ODONNELL, IJ
    MITCHELL, GF
    INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1980, 61 (02): : 213 - 219
  • [5] GAS-LIQUID-CHROMATOGRAPHY OF PHENYLALANINE AND ITS METABOLITES IN SERUM AND URINE OF VARIOUS HYPERPHENYLALANINEMIC SUBJECTS, THEIR RELATIVES, AND CONTROLS
    KITAGAWA, T
    SMITH, BA
    BROWN, ES
    CLINICAL CHEMISTRY, 1975, 21 (06) : 735 - 740
  • [6] GAS-LIQUID-CHROMATOGRAPHY OF PHENYLALANINE METABOLITES IN URINE AND SERA OF HYPERPHENYLALANINEMIC AND PHENYLKETONURIC PATIENTS
    KITAGAWA, T
    CLINICAL CHEMISTRY, 1974, 20 (12) : 1543 - 1547
  • [7] DETERMINATION OF CHLORAZEPATE AND ITS MAJOR METABOLITES IN BLOOD AND URINE BY ELECTRON-CAPTURE GAS-LIQUID-CHROMATOGRAPHY
    BROOKS, MA
    HACKMAN, MR
    WEINFELD, RE
    MACASIEB, T
    JOURNAL OF CHROMATOGRAPHY, 1977, 135 (01): : 123 - 131
  • [8] DETERMINATION OF PINAZEPAM AND ITS METABOLITES IN SERUM, URINE AND BRAIN BY GAS-LIQUID-CHROMATOGRAPHY AND MASS-SPECTROMETRY
    TREBBI, A
    GERVASI, GB
    COMI, V
    JOURNAL OF CHROMATOGRAPHY, 1975, 110 (02): : 309 - 319
  • [9] QUANTITATION OF NALTREXONE IN HUMAN URINE USING GAS-LIQUID-CHROMATOGRAPHY
    VEREBELY, K
    MULE, SJ
    JUKOFSKY, D
    PHARMACOLOGIST, 1974, 16 (02): : 225 - 225
  • [10] QUANTITATION OF PATULIN PATHWAY METABOLITES USING GAS-LIQUID-CHROMATOGRAPHY
    EHMAN, J
    GAUCHER, GM
    JOURNAL OF CHROMATOGRAPHY, 1977, 132 (01): : 17 - 26
12345