ENZYMICHROMISM - DETERMINATION OF THE DIELECTRIC-PROPERTIES OF AN ENZYME ACTIVE-SITE

被引：35
|
作者：
KANSKI, R [1 ]
MURRAY, CJ [1 ]
机构：
[1] UNIV ARKANSAS,DEPT CHEM & BIOCHEM,FAYETTEVILLE,AR 72701
来源：
TETRAHEDRON LETTERS | 1993年 / 34卷 / 14期
关键词：
D O I：
10.1016/S0040-4039(00)77589-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The negative solvatochromic and enzymichromic properties of 4-carbamidopyridinium cyclopentadienylide, 3, are presented. Tle 78 nm bathochromic shift of the long wavelength absorption band of 3 upon going from water to the horse liver alcohol dehydrogenase (HLADH)-NADH ternary complex is consistent with a low dielectric for the hydrophobic binding pocket of this enzyme.
引用
收藏
页码：2263 / 2266
页数：4
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