INITIATOR ELEMENTS AND REGULATED EXPRESSION OF THE HERPES-SIMPLEX VIRUS THYMIDINE KINASE GENE

被引：11

作者：

COOK, WJ

LIN, SM

DELUCA, NA

COEN, DM

机构：

[1] HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115

[2] UNIV PITTSBURGH,SCH MED,DEPT MOLEC GENET & BIOCHEM,PITTSBURGH,PA 15261

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 11期

关键词：

D O I：

10.1128/JVI.69.11.7291-7294.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Regulated expression of thymidine kinase mRNA in herpes simplex virus mutants harboring thymidine kinase promoters that lacked functional TATA boxes was largely unaffected by additional sequence alterations around the transcriptional start site. A strong initiator element increased the regulated expression of a TATA-containing promoter by 50% but did not affect that of the TATA-less promoter. Thus, initiator elements exert only small effects in this promoter context.

引用

页码：7291 / 7294

页数：4

共 50 条

[1] THYMIDINE KINASE GENE TRANSFER BY HERPES-SIMPLEX VIRUS
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