SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF 4-CARBAMOYL-5-ARYL-6-METHYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONES

被引：0
|
作者：
PINNA, GA
SARDU, F
CURZU, MM
SATTA, M
PEANA, A
CIGNARELLA, G
BARLOCCO, D
机构：
[1] DIPARTIMENTO SCI FARMACOL,I-07100 SASSARI,ITALY
[2] IST CHIM FARM & TOSSICOL,I-20131 MILAN,ITALY
来源：
FARMACO | 1992年 / 47卷 / 04期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A new series of 4-carbamoyl-5-aryl-6-methyl-4,5-dihydropyridazin-3(2H)-ones have been synthesized and tested for their antiinflammatory and analgesic properties. Amongst the test compounds, only 31 showed antiinflammatory activity, though of shorter duration than that of indomethacin, taken as reference drug. On the contrary, many derivatives displayed relevant analgesic activity, 4 - the only 4,5-dehydroderivative - being the most potent in the writhing test. In the hot plate test 3b, 3f and 3k were found to possess the most significant analgesic properties.
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页码：449 / 463
页数：15
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