FAST-TWITCH AND SLOW-TWITCH SKELETAL-MUSCLES EXPRESS THE SAME ISOFORM OF CALRETICULIN

被引：7
|
作者：
FLIEGEL, L
MICHALAK, M
机构：
[1] UNIV ALBERTA,HERITAGE MED RES CTR 417,DEPT BIOCHEM,CARDIOVASC DIS RES GRP,EDMONTON T6G 2S2,ALBERTA,CANADA
[2] UNIV ALBERTA,DEPT PEDIAT,EDMONTON T6G 2S2,ALBERTA,CANADA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 177卷 / 03期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/0006-291X(91)90634-J
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have characterized calreticulin protein and mRNA in fast-twitch and slow-twitch skeletal muscle. SR vesicles isolated from fast-twitch and slow-twitch skeletal muscles contain calreticulin protein immunoreactive with anti-calreticulin antibody. In addition, the fast-twitch skeletal muscle form of calreticulin is shown to be identical to slow-twitch form of the protein based on the identity of cDNA clones encoding fast-twitch and slow-twitch forms of the protein and hybridization of a fast-twitch or slow-twitch calreticulin cDNA probe to the same mRNA species. Based on these observations we conclude that fast-twitch and slow-twitch skeletal muscles express the same form of calreticulin. © 1991.
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页码：979 / 984
页数：6
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