CO-REGULATION OF PHENYTOIN AND TOLBUTAMIDE METABOLISM IN HUMANS

被引：0
|
作者：
TASSANEEYAKUL, W
VERONESE, ME
BIRKETT, DJ
DOECKE, CJ
MCMANUS, ME
SANSOM, LN
MINERS, JO
机构：
[1] FLINDERS UNIV,MED CTR,DEPT CLIN PHARMACOL,BEDFORD PK,SA 5042,AUSTRALIA
[2] UNIV S AUSTRALIA,SCH PHARM,ADELAIDE,SA,AUSTRALIA
来源：
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 34卷 / 06期
关键词：
PHENYTOIN; TOLBUTAMIDE; DRUG METABOLISM; CYTOCHROME-P-450; COREGULATION;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1 The disposition of phenytoin and tolbutamide was compared in eighteen healthy young adults separately administered single therapeutic doses (sodium phenytoin 300 mg, tolbutamide 500 mg) of the two drugs. 2 Within the group, ratios of ranges of total and unbound areas under the plasma concentration-time curves were similar for both drugs. 3 There were significant (P < 0.001) correlations between total (r = 0.88) and unbound (r = 0.86) areas under the plasma phenytoin and tolbutamide concentration-time curves. 4 The results are consistent with the involvement of the same cytochrome P-450 isoenzyme(s) in the metabolism of tolbutamide and phenytoin.
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页码：494 / 498
页数：5
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