INVITRO ACTIVITY OF BETA-LACTAM DRUGS AND SULBACTAM AGAINST CHLAMYDIA-TRACHOMATIS

被引：3
|
作者：
SEGRETI, J [1 ]
KAPELL, KS [1 ]
TRENHOLME, GM [1 ]
机构：
[1] RUSH MED COLL,CHICAGO,IL 60612
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 1992年 / 15卷 / 04期
关键词：
D O I：
10.1016/0732-8893(92)90027-Q
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We tested the in vitro activity of ampicillin, ampicillin-sulbactam, cefoperazone, cefoperazone-sulbactam, and sulbactam against 18 recent clinical isolates of Chlamydia trachomatis and two ATCC strains. Ampicillin (MIC50, 256mu-g/ml) and sulbactam (MIC50, 128-mu-g/ml) demonstrated some activity against C. trachomatis, but cefoperazone had little to no activity. At 2-3 dilutions below the MIC, C. trachomatis treated with ampicillin or sulbactam, but not cefoperazone, formed small inclusions that remained small on passage onto antibiotic-free McCoy cells. It appears that ampicillin and sulbactam suppress rather than kill C. trachomatis,
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页码：371 / 373
页数：3
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