DOPA-DECARBOXYLATION IN THE STRIATA OF RATS WITH UNILATERAL SUBSTANTIA-NIGRA LESIONS

被引：31
|
作者：
KANG, UJ [1 ]
PARK, DH [1 ]
WESSEL, T [1 ]
BAKER, H [1 ]
JOH, TH [1 ]
机构：
[1] CORNELL UNIV, COLL MED, BURKE MED RES INST, WHITE PLAINS, NY 10605 USA
来源：
NEUROSCIENCE LETTERS | 1992年 / 147卷 / 01期
关键词：
AROMATIC L-AMINO ACID DECARBOXYLASE; DOPA DECARBOXYLASE; PARKINSONS DISEASE; L-DOPA; 6-HYDROXYDOPAMINE; STRIATUM;
D O I：
10.1016/0304-3940(92)90773-Z
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The source and site of the DOPA decarboxylation to dopamine in Parkinson's disease (PD) and animal models of PD are controversial. Since most of aromatic L-amino acid decarboxylase (AADC) are lost along with the degenerating dopaminergic neurons. we addressed the possibility that other decarboxylases or a novel protein that is structurally different from AADC decarboxylate L-DOPA in the denervated striatum. Immunotitration of the extracts from the denervated striatum with AADC antibody showed that all activity can be attributed to AADC-immunoreactive protein. We then investigated if there are non-dopaminergic intrinsic striatal neurons that express AADC. No evidence of such neurons was noted by immunocytochemistry and in situ hybridization.
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页码：53 / 57
页数：5
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