PIMOZIDE-INDUCED EXTINCTION IN RATS - STIMULUS-CONTROL OF RESPONDING RULES OUT MOTOR DEFICIT

被引：131

作者：

FRANKLIN, KBJ

MCCOY, SN

机构：

[1] Department of Psychology, McGill University, Montreal, Que. H3A 1B1

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1979年 / 11卷 / 01期

关键词：

Akinesia; Dopamine; Neuroleptics; Pimozide; Reinforcement; Reward; Self-stimulation;

D O I：

10.1016/0091-3057(79)90299-5

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Rats stopped responding for electrical stimulation of the brain following pretreatment with the dopamine antagonist pimozide, as well as following truncation of brain stimulation trains. In either case the extinguished responding was temporarily reinstated on presentation of a light if the light had previously signalled reward but not if the light had had no such significance. These results indicate that pimozide reduces self-stimulation by abolishing the rewarding effect of brain stimulation rather than by interfering with motor ability. © 1979.

引用

页码：71 / 75

页数：5

共 32 条

[1] IMPORTANCE OF CATECHOLAMINE RELEASE BY NERVE IMPULSES FOR FREE OPERANT BEHAVIOR [J].