A PRACTICAL, ONE-POT PREPARATION OF DIISOPINOCAMPHEYLCHLOROBORANE

被引：1
|
作者：
SIMPSON, P
TSCHAEN, D
VERHOEVEN, TR
机构：
[1] Merck Sharp and Dohme Research Laboratories, Division of Merck & Co., Inc., P.O. Box 2000 Rahway
来源：
SYNTHETIC COMMUNICATIONS | 1991年 / 21卷 / 03期
关键词：
D O I：
10.1080/00397919108016769
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot preparation of the chiral reducing agent diisopinocampheylchloroborane (Ipc2BCl) from a-pinene and borane methyl sulfide has been developed. The procedure obviates isolation of the air and moisture sensitive reagent, making it useful for large scale operations. Asymmetric reduction of ketones using the in situ prepared Ipc2BCl is comparable to that using isolated reagent.
引用
收藏
页码：449 / 458
页数：10
相关论文
共 50 条
  • [1] A PRACTICAL, ONE-POT PREPARATION OF DIISOPINOCAMPHEYLCHLOROBORANE
    SIMPSON, P
    TSCHAEN, D
    VERHOEVEN, TR
    SYNTHETIC COMMUNICATIONS, 1991, 21 (15-16) : 1705 - 1714
  • [2] Practical one-pot stereospecific preparation of vicinal and 1,3-diols
    Bohman, Bjorn
    Flematti, Gavin R.
    Unelius, C. Rikard
    TETRAHEDRON LETTERS, 2017, 58 (01) : 75 - 77
  • [3] One-pot practical preparation of novel propargylic aryl and heteroaryl sulfides and sulfones
    Bonini, C
    Chiummiento, L
    Videtta, V
    SYNLETT, 2005, (20) : 3067 - 3070
  • [4] The 'one-pot' preparation of substituted benzofurans
    Csékei, M
    Novák, Z
    Timári, G
    Kotschy, A
    ARKIVOC, 2004, : 285 - 291
  • [5] Practical and scalable one-pot synthesis of arbekacin
    Zhang, Hongsen
    Wang, Chunxiao
    Liu, Kai
    Li, Chao
    Qiao, Renzhong
    REACTION CHEMISTRY & ENGINEERING, 2024, 9 (05) : 1179 - 1184
  • [6] A Practical, One-Pot Synthesis of Sulfonylated Pyridines
    Maloney, Kevin M.
    Kuethe, Jeffrey T.
    Linn, Kathleen
    ORGANIC LETTERS, 2011, 13 (01) : 102 - 105
  • [7] A new practical one-pot access to sulfonimidates
    Leca, D
    Fensterbank, L
    Lacôte, E
    Malacria, M
    ORGANIC LETTERS, 2002, 4 (23) : 4093 - 4095
  • [8] Practical One-Pot Double Functionalizations of Proline
    Huy, Peter
    Schmalz, Hans-Guenther
    SYNTHESIS-STUTTGART, 2011, (06): : 954 - 960
  • [9] A practical one-pot synthesis of dehydroalanine esters
    Shi, Qingyuan
    Zhu, Mengxiao
    Liang, Zhenchu
    Dong, Xu
    Zhang, Minyue
    Yang, Lili
    Sun, Pingping
    Xing, Chuanyi
    Zha, Xiaohao
    Li, Fei
    He, Hongliang
    Chen, Dongyin
    RSC ADVANCES, 2025, 15 (12) : 9359 - 9363
  • [10] One-pot preparation of 7-hydroxyquinoline
    Cameron, M
    Hoerrner, RS
    McNamara, JM
    Figus, M
    Thomas, S
    ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2006, 10 (01) : 149 - 152
12345