ADENOSINE RECEPTOR ANTAGONISTS POTENTIATE DOPAMINE RECEPTOR AGONIST-INDUCED ROTATIONAL BEHAVIOR IN 6-HYDROXYDOPAMINE-LESIONED RATS

被引：83
|
作者：
JIANG, H
JACKSONLEWIS, V
MUTHANE, U
DOLLISON, A
FERREIRA, M
ESPINOSA, A
PARSONS, B
PRZEDBORSKI, S
机构：
[1] COLUMBIA UNIV,DEPT NEUROL,BLACK BLDG,ROOM 307,650 W 168TH ST,NEW YORK,NY 10032
[2] COLUMBIA UNIV,DEPT PSYCHIAT,NEW YORK,NY 10032
来源：
BRAIN RESEARCH | 1993年 / 613卷 / 02期
关键词：
ADENOSINE; DOPAMINE; PARKINSONS DISEASE; ROTATIONAL BEHAVIOR; 6-HYDROXYDOPAMINE;
D O I：
10.1016/0006-8993(93)90925-D
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Adenosine receptor antagonists, DMPX, PACPX and theophylline, produce contralateral rotations in unilateral 6-hydroxydopamine-lesioned rats. DMPX and theophylline markedly increase rotations produced by bromocriptine (a dopamine D2 receptor agonist) and/or SKF38393A (a dopamine D1 receptor agonist). All of these effects are inhibited by CGS21680C (an adenosine A2 receptor agonist). These findings suggest synergistic interactions among D1, D2 and A2 receptors that may be relevant to the treatment of Parkinson's disease.
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页码：347 / 351
页数：5
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