INCONSISTENT BACTERICIDAL ACTIVITY OF TRIPLE-COMBINATION THERAPY WITH VANCOMYCIN, AMPICILLIN, AND GENTAMICIN AGAINST VANCOMYCIN-RESISTANT, HIGHLY AMPICILLIN-RESISTANT ENTEROCOCCUS-FAECIUM

被引：33
|
作者：
FRAIMOW, HS
VENUTI, E
机构：
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 07期
关键词：
D O I：
10.1128/AAC.36.7.1563
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Combination therapy with ampicillin, vancomycin, and gentamicin in vitro against several clinical isolates of vancomycin-resistant, highly ampicillin-resistant Enterococcus faecium, including VanA and VanB strains, was evaluated. The MICs of ampicillin were not significantly decreased by induction with vancomycin, and the combination of ampicillin and vancomycin was not inhibitory for any strain. Triple-combination therapy was least active against highly resistant VanA isolates, achieving a reduction of less than 1 log CFU at 24 h, but demonstrated slightly more activity against VanB strains.
引用
收藏
页码：1563 / 1566
页数：4
相关论文
共 50 条
  • [1] THE BACTERICIDAL ACTIVITY OF AMPICILLIN, DAPTOMYCIN, AND VANCOMYCIN AGAINST AMPICILLIN-RESISTANT ENTEROCOCCUS-FAECIUM
    ELMADY, A
    MORTENSEN, JE
    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1991, 14 (02) : 141 - 145
  • [2] BACTERICIDAL ACTIVITY OF VANCOMYCIN, DAPTOMYCIN, AMPICILLIN AND AMINOGLYCOSIDES AGAINST VANCOMYCIN-RESISTANT ENTEROCOCCUS-FAECIUM
    BINGEN, E
    LAMBERTZECHOVSKY, N
    LECLERCQ, R
    DOIT, C
    MARIANIKURKDJIAN, P
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1990, 26 (05) : 619 - 626
  • [3] NOVEL ANTIBIOTIC REGIMENS AGAINST ENTEROCOCCUS-FAECIUM RESISTANT TO AMPICILLIN, VANCOMYCIN, AND GENTAMICIN
    LANDMAN, D
    MOBARAKAI, NK
    QUALE, JM
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (09) : 1904 - 1908
  • [4] ANTIBIOTIC-TREATMENT OF EXPERIMENTAL ENDOCARDITIS DUE TO VANCOMYCIN-RESISTANT AND AMPICILLIN-RESISTANT ENTEROCOCCUS-FAECIUM
    WHITMAN, MS
    PITSAKIS, PG
    ZAUSNER, A
    LIVORNESE, LL
    OSBORNE, AJ
    JOHNSON, CC
    LEVISON, ME
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (10) : 2069 - 2073
  • [5] OUTBREAK OF VANCOMYCIN-RESISTANT, AMPICILLIN-RESISTANT, AND AMINOGLYCOSIDE-RESISTANT ENTEROCOCCUS-FAECIUM BACTEREMIA IN AN ADULT ONCOLOGY UNIT
    MONTECALVO, MA
    HOROWITZ, H
    GEDRIS, C
    CARBONARO, C
    TENOVER, FC
    ISSAH, A
    COOK, P
    WORMSER, GP
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (06) : 1363 - 1367
  • [6] Successful treatment of persistent bacteremia due to vancomycin-resistant, ampicillin-resistant Enterococcus faecium
    Mekonen, ET
    Noskin, GA
    Hacek, DM
    Peterson, LR
    MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE, 1995, 1 (03): : 249 - 253
  • [7] BACTERICIDAL ACTIVITY OF DAPTOMYCIN AGAINST VANCOMYCIN-RESISTANT ENTEROCOCCUS-FAECIUM IN AN INVITRO PHARMACOKINETIC MODEL
    BINGEN, E
    DOIT, C
    LAMBERTZECHOVSKY, N
    TOD, M
    PETITJEAN, O
    BOURGEOIS, F
    MARIANIKURKDJIAN, P
    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1991, 10 (12) : 1062 - 1065
  • [8] PRISTINAMYCIN FOR ENTEROCOCCUS-FAECIUM RESISTANT TO VANCOMYCIN AND GENTAMICIN
    WADE, J
    BAILLIE, L
    ROLANDO, N
    CASEWELL, M
    LANCET, 1992, 339 (8788): : 312 - 313
  • [9] SIMPLE TEST OF SYNERGY BETWEEN AMPICILLIN AND VANCOMYCIN FOR RESISTANT STRAINS OF ENTEROCOCCUS-FAECIUM
    GREEN, M
    BARBADORA, K
    WADOWSKY, RM
    JOURNAL OF CLINICAL MICROBIOLOGY, 1994, 32 (11) : 2837 - 2839
  • [10] Vancomycin-resistant Enterococcus faecium prosthetic valve endocarditis treated with daptomycin and ampicillin combination
    Krishnan, Anish
    Rajakumar, Irina
    Salmon, Joanne
    JOURNAL OF THE ASSOCIATION OF MEDICAL MICROBIOLOGY AND INFECTIOUS DISEASE CANADA (JAMMI), 2025,
12345