CELL-ADHESION AND EPITHELIAL DIFFERENTIATION

被引：35
|
作者：
FLEMING, S
机构：
[1] Department of Pathology, University of Edinburgh, Edinburgh, EH9 8AG, Teviot Place
来源：
JOURNAL OF PATHOLOGY | 1991年 / 164卷 / 02期
关键词：
CELL ADHESION; KIDNEY; EPITHELIUM; DIFFERENTIATION; WILMS TUMOR;
D O I：
10.1002/path.1711640202
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The differentiated function of epithelial tissues is dependent on the molecules which mediate the cohesion and polarization of the epithelium. Separate molecular families are responsible for the adhesion between adjacent cells and the adhesion between cells and the substratum. Using the kidney as a model of epithelial differentiation it has been shown that the assembly of a basal lamina containing the glycoprotein laminin and cadherin mediated intercellular adhesion are key events. The Wilms' tumour anti-oncogene plays a regulatory role in renal epithelial differentiation. Tissue modelling and tumour formation are both accompanied by reduced cell adhesion molecule function.
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页码：95 / 100
页数：6
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