OBSERVATIONS ON THE CHEMICAL NATURE OF LEAD IN HUMAN BLOOD-SERUM

被引：38

作者：

ALMODHEFER, AJA ^{[1
]}

BRADBURY, MWB ^{[1
]}

SIMONS, TJB ^{[1
]}

机构：

[1] UNIV LONDON KINGS COLL,DIV BIOMED SCI,PHYSIOL GRP,LONDON WC2R 2LS,ENGLAND

来源：

CLINICAL SCIENCE | 1991年 / 81卷 / 06期

关键词：

BLOOD; LEAD; SERUM;

D O I：

10.1042/cs0810823

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

1. The binding of lead to human blood serum, and components of serum, was studied by titration with the addition of Pb(NO3)2 solution, monitoring the free Pb2+ concentration with a Pb2+ electrode, and by equilibrium dialysis. 2. In fresh serum, about 4999 out of 5000 parts of added lead were bound. This suggests that the free Pb2+ concentration is around 1/5000th of the total lead concentration in the serum of normal subjects, i.e. about 1 x 10(-12) mol/l. 3. About 60% of the binding of lead in serum is abolished by standing in air, by dialysis or by treatment with N-ethylmaleimide. This appears to be due to the presence of thiol compounds, mainly cysteine. The remaining 40% appears to be due to protein, mainly albumin.

引用

页码：823 / 829

页数：7

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