SUSTAINED ENHANCEMENT OF NMDA RECEPTOR-MEDIATED SYNAPTIC POTENTIAL BY ISOPROTERENOL IN RAT AMYGDALAR SLICES

被引：32
|
作者：
GEAN, PW [1 ]
HUANG, CC [1 ]
LIN, JH [1 ]
TSAI, JJ [1 ]
机构：
[1] NATL CHENG KUNG UNIV,COLL MED,DEPT NEUROL,TAINAN,TAIWAN
来源：
BRAIN RESEARCH | 1992年 / 594卷 / 02期
关键词：
AMYGDALA; ISOPROTERENOL; N-METHYL-D-ASPARTATE; LONG-TERM POTENTIATION;
D O I：
10.1016/0006-8993(92)91146-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of isoproterenol (Iso) on synaptic transmission mediated by the N-methyl-D-aspartate (NMDA) receptors (EPSP(NMDA)) was investigated in slices of rat amygdala using intracellular recording techniques. EPSP(NMDA) was isolated pharmacologically by application of a solution containing the non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 10 muM) and GABA(A) receptor blocker bicuculline (20 muM). Superfusion of Iso (15 muM) produced a long-lasting enhancement of EPSP(NMDA). Pretreatment the slices with propranolol (10 muM) completely prevented the effect of Iso confirming the mediation by beta-adrenergic receptors. These results provide the direct evidence for adrenergic modulation of excitatory amino acid neurotransmission in the vertebrate central nervous system.
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页码：331 / 334
页数：4
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